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Best weapons by Mastery Rank

Of course weapon performance strongly depends on the mod setup on them, but here are generally the best weapons in Warframe, sorted by the Mastery Rank required to use them. Find them on the wiki to find out how to get them.
(There are no weapons that require a Mastery Rank above 15)

Mastery Rank Primary Secondary Melee
 0  Braton (Rifle)  Lato (Pistol) Skana (Sword)
Silva & Aegis (Sword & Shield)
 1  Karak (Rifle)
Strun (Shotgun)
 —  Magistar (Blunt)
 2  Boltor (Rifle)
Vectis (Sniper)
 Gammacor (Beam)
Sonicor (Pistol / Explosive)
Nami Skyla (Swords)
 3  Vulkar (Sniper)  Lex (Pistol) Kronen (Tonfa)
Tonbo (Polearm)
 4  Braton Vandal (Rifle)
Hek (Shotgun)
 Aklex (Pistols)
Despair (Thrown)
Hikou Prime (Thrown)
Spectra (Beam)
 Guandao (Polearm)
 5  Grakata (Rifle)
Ignis (Flamethrower)
Kohm (Shotgun)
Dread (Bow)
 Atomos (Beam) Atterax (Whip)
Cassowar (Polearm)
Orvius (Glaive)
 6  Soma (Rifle)
Flux Rifle (Beam)
Rubico (Sniper)
 Brakk (Shotgun)
Detron (Shotgun)
Galvacord (Whip)
Scoliac (Whip)
Serro (Polearm)
 7  Dera Vandal (Rifle)
Zarr (Grenade Launcher / Shotgun)
Sobek (Shotgun)
Soma Prime (Rifle)
 Hystrix (Rifle)
Lato Vandal (Pistol)
Synoid Gammacor (Beam)
Stubba (Rifle)
Caustacyst (Scythe)
Dual Keres (Swords)
Hirudo (Fists)
Tatsu (Two-Handed Nikana)
 8 Corinth (Shotgun)
Exergis (Shotgun)
Glaxion (Beam)
Komorex (Sniper)
Paris Prime (Bow)
Cyanex (Pistol)
Cycron (Beam)
Akstilleto (Rifles)
Akvasto (Pistols)
Pandero (Pistol)
Lex Prime (Pistol)
Dragon Nikana (Nikana)
Hate (Scythe)
Mios (Blade & Whip)
Prisma Skana (Sword)
 9  Phantasma (Beam / Shotgun)
Ignis Wraith (Flamethrower)
 Pox (Explosive)
Mara Detron (Shotgun)
Twin Grakatas (Rifles)
Twin Rogga (Pistols)
Lesion (Polearm)
Prisma Dual Cleavers (Cleavers)
 10  Amprex (Beam)
Arca Plasmor (Shotgun)
Lanka (Sniper)
Strun Wraith (Shotgun)
Tenora (Rifle)
Quanta Vandal (Beam)
Quartakk (Rifle)
 Akstilleto Prime (Rifles)
Secura Dual Cestra (Rifles)
Spectra Vandal (Beam)
Staticor (Pistols / Explosive)
Vaykor Marelok (Pistol)
 Glaive Prime (Glaive)
Broken War (Sword)
Paracesis (Heavy Blade)
Prisma Obex (Fists)
Reaper Prime (Scythe)
Redeemer Prime (Gunblade)
War (Sword)
 11  Synapse (Beam)
Prisma Grakata (Rifle)
 Dual Toxocyst (Pistols)
Prisma Twin Gremlins (Rifles)
 Nami Skyla Prime (Swords)
Skiajati (Nikana)
 12  Sybaris Prime (Rifle)
Rubico Prime (Sniper)
Vaykor Hek (Shotgun)
Glaxion Vandal (Beam)
 Akvasto Prime (Pistols)
Akjagara Prime (Rifles)
Aksomati Prime (Rifles)
Nikana Prime (Katana)
Orthos Prime (Polearm)
Silva & Aegis Prime (Sword & Shield)
 13 Kuva Kohm (Shotgun)
Shedu (Arm-Cannon)
Tigris Prime (Shotgun)
Kuva Brakk (Shotgun)
Kuva Twin Stubbas (Rifles)
Pyrana Prime (Pistol)
 Galatine Prime (Sword)
Kronen Prime (Tonfa)
Kuva Shildeg (Hammer)
 14 Opticor (Rifle / Cannon)
Opticor Vandal (Rifle / Cannon)
Supra Vandal (Rifle)
Vectis Prime (Sniper)
Tiberon Prime (Rifle)
 Euphona Prime (Pistol)  Gram Prime (Sword)
Ninkondi Prime (Nunchaku)
Venka Prime (Claws)
 15  Kuva Chakkhurr (Rifle)  —  —


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